Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia
نویسندگان
چکیده
منابع مشابه
Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia
Background Focal cerebral ischemia induces distinct neuroinflammatory processes. We recently reported the extracellular phosphor-glyco-protein osteopontin (OPN) to directly affect primary microglia in vitro, promoting survival while shifting their inflammatory profile towards a more neutral phenotype. We here assessed the effects of OPN on microglia after stroke in vivo, with focus on infarct d...
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BACKGROUND AND PURPOSE We observed that microRNA-424 (miR-424) significantly decreased in an miRNA profile of circulating lymphocytes of patients with ischemic stroke. The present study focused on the potential and mechanism of miR-424 in protecting ischemic brain injury in mice. METHODS Cerebral ischemia was induced by middle cerebral artery occlusion in C57/BL6 mice. Cerebral infarction vol...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2017
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2017/7189421